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Amyloid-Ablagerungen und Alzheimer: Kann Nattokinase ein Schlüssel zur Prävention sein?

Amyloid Deposits and Alzheimer's: Can Nattokinase Be a Key to Prevention?

Alzheimer's disease is a progressive neurodegenerative disease that primarily affects older people and is characterized by memory loss and cognitive and functional impairments. One of the central hypotheses in Alzheimer's research is the amyloid cascade hypothesis, which sees the accumulation of amyloid beta (Aβ) peptides in the brain as an early driving factor in disease pathology. More recently, a study by Shivraj Naik has drawn attention to a naturally occurring enzyme, nattokinase, which has the potential to dissolve amyloid plaques, potentially preventing the development or progression of Alzheimer's disease.

The Amyloid Hypothesis:

Amyloid beta is a protein fragment normally produced in the brain. However, in Alzheimer's patients, these protein fragments cluster, forming plaques and disrupting communication between neurons. Over time, this leads to a deterioration in brain function. These deposits are a key feature of Alzheimer's disease and are suspected of having neurotoxic effects.

Nattokinase – a potential source of hope:

Nattokinase is an enzyme derived from natto, a traditional Japanese food made from fermented soybeans. It is known for its ability to dissolve blood clots and thus improve blood circulation. Shivraj Naik's study showed that nattokinase also has the ability to break down amyloid fibrils that lead to plaques. This suggests that nattokinase has the potential to have a preventative effect in the early stages of Alzheimer's disease.

Scientific principles and research results:

Naik's research demonstrated that nattokinase can degrade amyloid aggregates in vitro (i.e. in the test tube). The use of nattokinase resulted in a significant reduction in amyloid fibrils. These results are promising, but need to be confirmed by human clinical trials to assess the safety and effectiveness of nattokinase as a preventative or therapeutic measure against Alzheimer's disease.

What does this mean for Alzheimer's prevention?

Although the amyloid cascade hypothesis has not yet been conclusively confirmed, much of the current research is aimed at reducing Aβ deposits. Nattokinase could play a role in future prevention strategies, especially if further studies confirm its ability to safely dissolve amyloid plaques.


The search for effective prevention measures and treatments for Alzheimer's is more urgent than ever. Shivraj Naik's work provides exciting new insights into how nattokinase could help reduce the burden of amyloid plaques. However, it is important not to overinterpret the results. To date, there are no clinical data supporting the use of nattokinase in Alzheimer's patients. Further research, including clinical trials, is needed to fully understand the role of this enzyme in the prevention and treatment of Alzheimer's disease.

Nattokinase's potential to bridge nutrition and neurology demonstrates exciting interdisciplinary approaches in modern medicine and opens up new possibilities for combating neurodegenerative diseases.

Link to the study.

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