David Sinclair, renowned biologist and professor at Harvard Medical School, has caused quite a stir with his research on longevity and his book "The End of Ageing". His theories on healthy ageing and extending lifespan, particularly through the use of NMN (nicotinamide mononucleotide), have fascinated many people in Germany and around the world. Here is an overview of Sinclair's approaches and the role of NMN in his research.
Sinclair's basic thesis on ageing and the importance of NMN
Sinclair believes that ageing is not an inevitable process, but a treatable disease. He believes that through certain lifestyle changes and the use of nutritional supplements such as NMN, we can significantly extend our lifespan and age more healthily. Interest in this promising substance is growing in Germany.
Its theory is based on the idea that our cells increasingly lose their epigenetic information over the course of our lives. NMN plays a key role in this, as it supports cell metabolism as a precursor of NAD+ and may be able to slow down the ageing process.
Sinclair's recommendations for a longer life
Diet and lifestyle
- Intermittent fasting: Sinclair recommends limiting the daily eating time to around 8-10 hours.
- Calorie reduction: An overall reduction in calorie intake should have a life-prolonging effect.
- Plant-based diet: Lots of vegetables and fruit, few animal products.
- Regular exercise: Sinclair emphasizes the importance of physical activity.
- Exposure to cold: Regular brief exposure to cold is said to stimulate the metabolism.
- Stress reduction: Meditation and sufficient sleep are important factors for healthy ageing.
Food supplements with a focus on NMN
- Dose: 1 gram daily
- Effect: NMN is a precursor of NAD+, an important molecule for cell metabolism.
- In NMN Germany, interest in this substance is growing due to its potential life-prolonging effect.
2. resveratrol
Resveratrol is a plant substance found in the skin of red grapes. In his research, Sinclair discovered that resveratrol activates a group of enzymes called sirtuins. Sirtuins play an important role in the repair of DNA damage and the regulation of cell metabolism.
Effect of resveratrol:
- Activates sirtuins, which improve cell health.
- Improves the function of mitochondria, the powerhouses of cells.
- Has anti-inflammatory and antioxidant properties.
3. metformin
Metformin is a drug traditionally used to treat type 2 diabetes. However, metformin has also been shown to affect age-related processes. Studies have shown that metformin can extend the lifespan of animals by improving sugar utilization in the body and reducing inflammation.
Effect of metformin:
- Lowers blood sugar levels and improves insulin sensitivity.
- Has antioxidant and anti-inflammatory effects.
- Can reduce the risk of age-related diseases such as cardiovascular disease and cancer.
4. spermidine
Spermidine is a natural compound found in many foods such as wheat germ, soy and mushrooms. Spermidine is known to activate processes in the body called autophagy. Autophagy is the process by which cells break down and recycle damaged or unneeded components.
Effect of spermidine:
- Promotes autophagy, which helps cleanse and renew cells.
- Can improve brain function and slow down neurodegenerative diseases.
- Has anti-inflammatory and antioxidant properties.
Quercetin
Quercetin is a plant flavonoid found in many fruits and vegetables. It has strong antioxidant and anti-inflammatory properties and can promote health in many ways.
Effect of quercetin:
- Protects cells from oxidative stress.
- Reduces inflammation in the body.
- May boost immune function and improve overall health.
Critical review of Sinclair's approach and NMN
While Sinclair's research and recommendations, particularly on NMN, have attracted a lot of attention, there are also critical voices:
- Scientific basis: many of Sinclair's recommendations, including NMN, are based on laboratory studies and animal studies. Their effectiveness in humans is often not yet sufficiently proven.
- Individual differences: What works for Sinclair may not be suitable for everyone.
- Potential risks: Long-term use of high doses of supplements such as NMN may have unknown side effects.
Practical implementation of Sinclair's recommendations and NMN intake
If you are interested in Sinclair's approach and NMN, here are some tips on how to implement it:
- Start slowly: Introduce changes gradually rather than switching everything at once.
- Consult a doctor: Discuss the use of NMN and other supplements with a medical professional.
- Prioritize lifestyle changes: Focus on healthy eating, regular exercise and getting enough sleep first.
- Choose high quality products: When taking NMN, look for quality and reputable manufacturers.
Conclusion: NMN and the future of longevity research
David Sinclair's approach to extending lifespan, particularly through the use of NMNs, is fascinating and offers interesting perspectives. His recommendations on diet, lifestyle and supplements have the potential to improve health and possibly longevity.
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Research into NMN and other longevity molecules is progressing steadily, and it remains exciting to see what role NMN will play in the future of healthcare in Germany.
Sources:
- [David Sinclair's official website]
- [Harvard Medical School - David Sinclair's research]
- [German Center for Aging Research]
- [Federal Institute for Risk Assessment - Food supplements]
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